Killing cancer cells with sound waves. HistoSonics’ Ed...

Killing cancer cells with sound waves. HistoSonics’ Edison system uses a water-filled membrane to transmit focused ultrasound into the body. Scientists are Ultrasound waves—sound waves with frequencies higher than humans can hear—have been used as a cancer treatment before, albeit in a broad-brush approach: high-intensity bursts of ultrasound can Researchers from the University of Michigan are showing how noninvasive sound waves can successfully destroy tumors in mice by tearing down cancer cell walls. High intensity focused ultrasound (HIFU) is a treatment that aims to kill cancer cells with high frequency sound waves. Ultrasound waves—sound waves with frequencies higher than humans can hear—have been used as a cancer treatment before, albeit in a broad-brush approach: high-intensity bursts of ultrasound can As science continues to fight cancer, one obstacle has been the safe and easy removal of cancer cells from the body for study. Image credit: Marcin Szczepanski, Michigan Engineering Noninvasive sound technology developed at the University of Michigan breaks down liver tumors in rats, kills cancer cells and spurs the immune Noninvasive sound technology developed at the University of Michigan breaks down liver tumors in rats, kills cancer cells, and spurs the The United States Food and Drug Administration has approved the use of sound waves to break down tumors—a technique called histotripsy—in humans for The bubbles rapidly expand and collapse. A new ally in that fight might. In a preclinical study, In contrast, sound waves kill the cancer cells by breaking their cell walls, releasing tumor antigens that then trigger the body's defense systems. The resulting bubbles expand and collapse Ultrasound waves—sound waves with frequencies higher than humans can hear—have been used as a cancer treatment before, albeit in a broad-brush approach: high-intensity bursts of Histotripsy works by using targeted ultrasound waves to form microbubbles within the tumor. The By directing focused ultrasound waves right into a tumor, we can quickly disrupt and break down cancer cells by forming tiny bubbles. The research, published in Molecular Cancer Therapeutics, focused on melanoma models but has implications for other cancer types including pancreatic cancer. When Noninvasive sound technology developed at the University of Michigan breaks down liver tumors in rats, kills cancer cells and spurs the immune system to prevent further spread -- an Histotripsy is a non-invasive process that uses sound waves to completely eliminate cancer tumors. Another rat study shed more light on this phenomenon revealing that that histotripsy exposes cancer cell antigens to the immune system, which the immune system The research on new ways to trigger programmed cell death of tumor cells can lead to improved cancer treatments. Histotripsy works by using targeted ultrasound waves to form microbubbles within the tumor. The forces created as those bubbles form and By directing focused ultrasound waves right into a tumor, we can quickly disrupt and break down cancer cells by forming tiny bubbles. It uses ultrasound to break up cancer cells from within by targeting them with sound waves at frequencies that cause a kind of turbulence inside the cell known as Yes, sound waves can be used for cancer treatment through a technique known as High-Intensity Focused Ultrasound (HIFU). The forces created as those bubbles form and collapse cause the mass to break apart, killing In cancer treatment, ultrasound waves are concentrated onto a small area of a tumour to destroy it. The study was published in Cell Death & Differentiation. HIFU focuses high-frequency sound waves on a specific area, Sound waves can cross the blood-brain barrier and could deliver chemotherapy to complex and treatment-resistant glioblastomas. Ultrasound waves—sound waves with frequencies higher than humans can hear—have been used as a cancer treatment before, albeit in a broad-brush approach: high-intensity bursts of ultrasound can Photo: Erica Bass/Michigan Medicine Histotripsy works by using targeted ultrasound waves to form microbubbles within the tumor. Like radiation therapy, doctors point an The activation of these agents by low-intensity ultrasound waves can induce tumor killing through oxidative damage and eventual cell death in targeted cancer cells, enabling a modality for tumor cell Mathematical models have been developed to predict how cells might react to different frequencies of ultrasound, suggesting a tuned sound wave could cause a cancer cell’s membrane to rupture. These violent and mechanical stressors destroy enough cancer cells to break up the tumor’s structure. The forces created as those bubbles form and Histotripsy works by using targeted ultrasound waves to form microbubbles within the tumor. It is only available in specific centres or as part of a clinical trial.


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